does sertraline come in liquid form

by Elliot Hoppe DVM Published 1 year ago Updated 4 months ago

A medicine commonly used to treat depression, sertraline (Zoloft), is available as a tablet or a concentrated oral liquid. The oral liquid form is very potent and must first be diluted in a specific beverage to make it easier to swallow.Jul 26, 2019


The significant increases in 5-HT within the extracellular fluid of the brain following treatment with SSRIs are associated with anticonvulsant effects. Literature evaluating the use of SSRIs for the treatment of epilepsy in humans is limited.

Is sertraline an anticonvulsant?

The research suggests Sertraline is perhaps more effective at tackling anxiety than depression. In general, however, the subjects taking the real antidepressants were found to be twice as likely as the placebo participants to say their mental health felt better overall.

Does sertraline work in the CNS?


  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin Uptake Inhibitors
  • Fluoxetine
  • Citalopram
  • Sertraline

How is sertraline synthesized?

Zoloft comes in tablet or liquid form. In general, Zoloft is taken once daily, with or without food. Swallow the tablets whole—not chewed or crushed. If taking the liquid form of Zoloft, combine the prescribed amount of medication with one-half cup of liquid (water, ginger ale, lemon-lime soda, lemonade, or orange juice), and be sure to ...

Does Zoloft come in a liquid form?


How do you take liquid sertraline?

How is this medicine (Sertraline Oral Liquid) best taken?Only use the measuring device that comes with this liquid drug.Mix liquid with 1/2 cup of water, ginger ale, lemon-lime soda, lemonade, or orange juice.After mixing, take your dose right away. ... This medicine may look hazy after mixing.More items...•

What is liquid sertraline used for?

SERTRALINE (SER tra leen) is used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD) or social anxiety.

What flavor is sertraline liquid?

Dosage Forms and Strengths Sertraline Hydrochloride Oral Solution USP is a clear, colorless peppermint flavored liquid containing sertraline hydrochloride equivalent to 20 mg of sertraline per mL and 12% alcohol.

How much is liquid sertraline?

The cost of a bottle of sertraline oral solution is as low as $23 with a free GoodRx discount. How much is sertraline without insurance? Without insurance, the cost of 30 tablets of sertraline 100 mg is about $7 with a free GoodRx discount.

Is there liquid antidepressants?

Summary. SSRIs: As of May 2022, liquid formulations are available in the US for all but one of the six SSRIs—for citalopram, escitalopram, fluoxetine, paroxetine, and sertraline, but not for fluvoxamine. TCAs: A liquid formulation is available for nortriptyline.

Can sertraline be dissolved in water?

Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol.

Can I crush sertraline tablets?

Sertraline tablets may be taken with or without food. The tablets should not be chewed or crushed; they should always be swallowed whole, with a drink of water.

Can you overdose on liquid Zoloft?

An overdose on almost any medication, including Zoloft, is possible. Medications are dosed specifically based on many factors, including: Weight. Age.

How long does it take sertraline to dissolve?

Half-Life Of Zoloft (Sertraline) Zoloft (sertraline) has a half-life of 24 to 26 hours, which means that it will take a person roughly a day for the drug's presence to reduce to half the amount. In another 24 hours, the amount in a person's body will decrease to 25% or half of the remaining amount.

Is Zoloft and sertraline the same thing?

Sertraline belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Sertraline is sold under the brand name Zoloft, and there are also generic versions. It is available at most pharmacies.

Why does sertraline oral solution have to be diluted?

Direct administration of the concentrated, undiluted solution Is astringent and may numb the mouth and tongue for at least a day. Sertraline liquid oral concentrate is produced in a 20-mg/mL concentration. The solution must be diluted before use to make the preparation more palatable.

Does sertraline cause weight gain?

Antipsychotic drugs, antidepressants , and mood stabilizers are common drugs that have the most potential to increase weight gain. All 12 of the leading antidepressants, including fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro), make gaining weight more likely.

Why does sertraline liquid need to be diluted?

Direct administration of the concentrated, undiluted solution Is astringent and may numb the mouth and tongue for at least a day. Sertraline liquid oral concentrate is produced in a 20-mg/mL concentration. The solution must be diluted before use to make the preparation more palatable.

Is sertraline an antidepressant?

Sertraline is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It's often used to treat depression, and also sometimes panic attacks, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).

Can you overdose on liquid Zoloft?

An overdose on almost any medication, including Zoloft, is possible. Medications are dosed specifically based on many factors, including: Weight. Age.

What can you mix liquid Zoloft with?

If you are taking the oral liquid, use the dropper provided to measure your dose and mix it with 1/2 cup (4 ounces) of water, ginger ale, lemon-lime soda, lemonade, or orange juice. Do not mix this medicine with any other liquid. Drink it right away after mixing.

How to use Zoloft?

Follow all instructions closely. Only use the measuring device that comes with this liquid drug. Mix liquid with 1/2 cup of water, ginger ale, lemon-lime soda, lemonade, or orange juice.

How long does it take for Zoloft to work?

In depression, sleep and appetite may get better soon after starting Zoloft (sertraline oral liquid). Other low mood signs may take up to 4 weeks to get better. This medicine may raise the chance of a broken bone. Talk with the doctor. This medicine may raise the chance of bleeding.

What if you are allergic to Zoloft?

If you are allergic to Zoloft (sertraline oral liquid); any part of Zoloft (sertraline oral liquid); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have liver disease . If you are taking any of these drugs: Linezolid or methylene blue .

What to do if you take Zoloft?

All people who take Zoloft (sertraline oral liquid) need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.

Can you stop taking Zoloft?

Avoid driving and doing other tasks or actions that call for you to be alert until you see how Zoloft (sertraline oral liquid) affects you. Do not stop taking Zoloft (sertraline oral liquid) all of a sudden without calling your doctor. You may have a greater risk of side effects.

Can Zoloft cause a fast heartbeat?

Sometimes, this has led to another type of unsafe abnormal heartbeat (torsades de pointes). Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out.

Can you take Zoloft with a prescription?

You must check to make sure that it is safe for you to take Zoloft (sertraline oral liquid) with all of your drugs and health problems.

How does sertraline work?

It works by helping to restore the balance of a certain natural substance (serotonin) in the brain. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using sertraline and each time you get a refill.

How to report Sertraline side effects?

You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before taking sertraline, tell your doctor or pharmacist if you are allergic to it ; or if you have any other allergies.

How to mix a syringe?

Mix the dose with a half cup (4 ounces/120 milliliters) of water, ginger ale, lemon-lime soda, lemonade, or orange juice. Drink all of the mixture immediately. Do not use other liquids to mix this drug. The mixture may appear cloudy, which is normal and harmless.

Can you mix a medicine dropper with another liquid?

If you have any questions, ask your doctor or pharmacist.This medication must be mixed with another liquid before use. Just before taking, carefully measure the dose using the medicine dropper provided. Do not use a household spoon because you may not get the correct dose.

Can water pills cause hyponatremia?

Older adults may also be more likely to develop a type of salt imbalance ( hyponatremia ), especially if they are taking "water pills" (diuretics). Loss of coordination can increase the risk of falling.Children may be more sensitive to the side effects of the drug, especially loss of appetite and weight loss.

Does sertraline help with anxiety?

It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. Sertraline is known as a selective serotonin reuptake inhibitor (SSRI).

What drugs can you take with sertraline?

Monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, phenelzine, and tranylcypromine. Taking these drugs with sertraline increases your risk of serotonin syndrome. You must also wait 14 days between taking these drugs and taking sertraline. Linezolid, intravenous methylene blue.

What are the symptoms of serotonin?

The symptoms of serotonin syndrome include hallucinations and delusions, agitation, coma, fast heart rate, and changes in blood pressure. They also include dizziness, loss of consciousness, seizures, shakiness, muscle tremor or stiff muscles, sweating, nausea, and vomiting. Severe allergic reaction: This drug can sometimes cause a severe allergic ...

How does serotonin help with depression?

This drug works by increasing the amount of serotonin, a natural substance in your brain, that helps maintain mental health balance. This can improve the symptoms of depression and anxiety.

What are the side effects of a syringe?

Side effects for adults and children can include: nausea, loss of appetite, diarrhea, and indigestion. change in sleep habits, including increased sleepiness and insomnia. increased sweating.

Can Sertraline interact with other medications?

Sertraline oral tablet can interact with other medications, vitamin s, or herbs you may be taking . An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully.

Is Sertraline a generic?

Sertraline oral tablet is a prescription drug that’s available as the brand-name drug Zoloft. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. This drug is also available as an oral solution.

Can you take sertraline with amitriptyline?

Tricyclic antidepressants such as amitriptyline, desipramine, and imipramine. Taking sertraline with these drugs may cause these drugs to build up in your body. Your doctor may need to adjust your dosage of tricyclic antidepressants while you take sertraline.

What is a sertraline?

Sertraline. More... Sertraline is a selective serotonin reuptake inhibitor (SSRI) used in the therapy of depression, anxiety disorders and obsessive-compulsive disorder. Sertraline therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute ...

Where is sertraline metabolized?

Sertraline is heavily metabolized in the liver and has one major active metabolite. It undergoes N-demethylation to form N-desmethylsertraline, which is much less potent in its pharmacological activity than sertraline. In addition to N-demethylation, sertraline metabolism involves N-hydroxylation, oxidative deamination, and finally, glucuronidation. The metabolism of sertraline is mainly catalyzed by CYP3A4 and CYP2B6, with some activity accounted for by CYP2C19 and CYP2D6.

How much sertraline is in the liver?

Post-mortem studies in humans have measured liver tissue concentrations of 3.9–20 mg/kg for sertraline and between 1.4 to 11 mg/kg for its active metabolite, N-desmethyl-sertraline (DMS).

How old is too old to take sertraline?

Sertraline has been tested in children 6 to 17 years of age and, in effective doses, has not been shown to cause different side effects or problems than it does in adults. However, the effects of long-term use of sertraline on the growth, development, and maturation of children and adolescents are unknown.

What are antidepressants used for?

Antidepressants, especially serotonin -reuptake inhibitors, also are employed in the management of post-traumatic stress disorder, marked by anxiety, startle, painful recollection of the traumatic events, & disturbed sleep. ... The serotonin -reuptake inhibitors are agents of choice in obsessive-compulsive disorder, as well as in possibly related syndromes of impulse dyscontrol or obsessive preoccupations, including compulsive habits, bulimia (but usually not anorexia) nervosa, & body dysmorphic disorder. While their benefits may be limited, serotonin -reuptake inhibitors offer an important advance in the medical treatment of these often chronic & sometimes incapacitating disorders for which no other medical treatment, by itself, has been consistently effective, the effectiveness of pharmacological treatment of these commonly treatment-resistant disorders is greatly enhanced by use of behavioral treatments. In addition to the wide use of modern antidepressants to treat depression commonly associated with general medical illnesses, several psychosomatic disorders may respond at least partly to treatment with antidepressants of the tricyclic, MAO inhibitor, or serotonin -reuptake inhibitor types. These include chronic pain disorders, including adiabetic & other peripheral neuropathic syndromes (for which tertiaryamine tricyclics are probably superior to fluoxetine ); fibromyalgia; peptic ulcer & irritable bowel syndrome; chronic fatigue; cataplexy; tics; migraine; & sleep apnea. /Antidepressants; Serotonin -reuptake inhibitors/

Does sertraline increase serotonin?

Sertraline selectively inhibits the reuptake of serotonin ( 5-HT) at the presynaptic neuronal membrane, thereby increasing serotonergic activity. This results in an increased synaptic concentration of serotonin in the CNS, which leads to numerous functional changes associated with enhanced serotonergic neurotransmission. These changes are believed to be responsible for the antidepressant action and beneficial effects in obsessive-compulsive (and other anxiety related disorders). It has been hypothesized that obsessive-compulsive disorder, like depression, is also caused by the disregulation of serotonin. In animal studies, chronic administration of sertraline results in down-regulation of brain norepinephrine receptors. Sertraline displays affinity for sigma-1 and 2 receptor binding sites, but binds with stronger affinity to sigma-1 binding sites. In vitro, sertraline shows little to no affinity for GABA, dopaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors. It exerts weak inhibitory actions on the neuronal uptake of norepinephrine and dopamine and exhibits no inhibitory effects on the monoamine oxidase enzyme.

Is sertraline a conjugate base?

It is a conjugate base of a sertraline (1+). It derives from a hydride of a tetralin. Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [ Citalopram] and [ Fluoxetine ]. Despite marked structural differences between compounds in this drug class, ...

How long does a diluted sulfate solution numb your tongue?

Direct administration of the concentrated, undiluted solution is astringent and may numb the mouth and tongue for at least a day , even if the mouth is rinsed extensively.

Can you administer sertraline undiluted?

To administer sertraline oral concentrate safely, it must be diluted immediately before administration.

Is it normal to have a slight haze after mixing sertraline?

It is important to inform caregivers and patients that a slight haze may appear after mixing, which is normal. Most commercially available sertraline products include a warning to dilute before use on the main panel of the manufacturer’s carton and bottle (figure).

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